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Associations of serum protein concentrations with serum metabolites, average daily gain, and health measures during the early stages of growth in Holstein dairy calves.

B. J. Tverdy

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06-23-2020

Abstract:

262
Associations of serum protein concentrations with serum metabolites, average daily gain, and health measures during the early stages of growth in Holstein dairy calves.
B. J. Tverdy*1, C. Y. Tsai1, H. C. Hung1, P. Rezamand1, W. J. Price2. 1Department of Animal and Veterinary Science, University of Idaho Moscow, ID, 2Statistical Programs, College of Agricultural and Life Sciences, University of Idaho Moscow, ID.

An objective of this study was to determine the associations of passive transfer status, by assessment of serum total protein (TP), with serum metabolites, daily gain, morbidity, and mortality in neonatal Holstein dairy calves (n = 1,558). Calves were purchased from dairy farms in the western United States and placed in a calf ranch as one day old. Calves were assigned an individual electronic identification and entered into Feedlot Health Management Services proprietary software, iFHMS (Feedlot Health Management Services, Preston, ID). Cause-specific morbidity and mortality was recorded for each calf daily from entry to exiting or death. A 5-mL tube of blood was collected from each animal at 48 � 6h post-arrival. Whole blood was centrifuged at 2000 g for 10 min and serum was stored at −20�C. Serum TP was measured using a digital refractometer. Calves were categorized based on proposed AVMA serum TP guidelines into poor (TP <5.1 g/dL, n = 159, mean � SD 4.68 � 0.31 g/dL), fair (5.1 < TP ≤5.7 g/dL, n = 399, 5.45 � 0.19 g/dL), good (5.8 ≤ TP ≤6.1 g/dL, n = 322, 5.96 � 0.11 g/dL) and excellent (TP >6.1 g/dL, n = 751, 5.96 � 0.11 g/dL). Samples were analyzed using a reverse-phase HPLC using a C18 column for vitamins and a colorimetric assay for glucose. Data were analyzed using GLIMMIX and logistic regression models with significance declared at P ≤ 0.05. Significant differences between poor and excellent were observed in mortality and ear disease treatments (P < 0.05 for both). Differences were observed when comparing poor and fair to good and excellent TP categories for serum glucose (P < 0.05). Differences were also detected when comparing poor with all other groups for serum retinol (P = 0.001). Serum β-carotene and α-tocopherol were different when comparing all TP categories against the excellent (P < 0.05 for both). Average daily gain at 90 d and overall was not statistically different among TP categories. Overall, serum metabolites were different among TP categories, suggesting an associative relationship with health and the immune system.

Keywords: passive transfer, metabolites.

Biography: Benjamin�is a practicing bovine practitioner in Idaho working on completing�a Masters of Science�in Animal Sciences at the University of Idaho.