Adsa Logo White Adsa Title White

The effect of metaphylactic use of tildipirosin for the control of respiratory disease associated with long-distance transportation of dairy calves.

M. Celestino

Events

06-23-2020

Abstract:

270
The effect of metaphylactic use of tildipirosin for the control of respiratory disease associated with long-distance transportation of dairy calves.
M. Celestino*1, L. Fernandes1, P. Menta1, D. Paiva1, T. Ribeiro1, T. Silva1,2, R. Neves1,3, M. Ballou1, V. Machado1. 1Texas Tech University Lubbock, TX, 2University of S�o Paulo Pirassununga, S�o Paulo, Brazil, 3Purdue University West Lafayette, IN.

The objective of this study was to evaluate the efficacy of 2 metaphylactic strategies using tildipirosin in controlling bovine respiratory disease (BRD) incidence for dairy calves that were transported within their 1st wk of life. A total of 2,100 calves were randomly allocated into 3 groups at 3 d after arrival: META1 calves received a single subcutaneous (SQ) injection of tildipirosin (Zuprevo, Merck Animal Health) at enrollment; META2 calves received one SQ injection of tildipirosin at enrollment and 17 d later; and CON calves remained as untreated controls. A validated scoring chart (UC Davis) was used for BRD diagnosis. Ultrasonography (US) of the lungs was assessed for a random subset of 200 calves per treatment-group, and blood collected for the measurement of stress and inflammatory markers. Data were analyzed using multivariate logistic regression, Cox Proportional Hazards models, repeated measures ANOVA, and multivariate linear regression models. Metaphylactic use of tildipirosin did not affect BRD incidence (P = 0.44), presence of lung lesions diagnosed by US at weaning (P = 0.99) and average daily gain (P = 0.25). There was a tendency for META2 to decrease mortality in comparison to CON calves (P = 0.05). At 27 d after enrollment, calves enrolled in META 2 had decreased concentrations of haptoglobin and aspartate aminotransferase, and decreased neutrophil to lymphocyte ratio compared with CON calves (P < 0.05). Additionally, CON calves had increased concentration of globulins and lower albumin to globulin ratio than META2 calves at the end of the weaning period (P < 0.05). Metaphylactic use of tildipirosin in calves transported within the first week of life did not reduce BRD incidence before weaning despite reducing concentrations of inflammatory markers and enhancing immune parameters. Metaphylaxis tended to decrease mortality during the pre-weaning period.

Keywords: calves, metaphylaxis, bovine respiratory disease (BRD).

Biography: �Acknowledgements: Maria Luiza Celestino is a second-year master's student at Texas Tech University Department of Animal Science. She got her Doctor of Veterinary Medicine degree at University of Sao Paulo in 2018. Her focus in the veterinary field is dairy calves' nutrition, management and health. Her master's thesis revolves around strategies to improve health of transported high-risk dairy calves specially regarding bovine respiratory disease in the pre-weaning period.