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Reproductive outcomes associated with delayed clinical cure of metritis in dairy cows.

C. Figueiredo

Abstract:

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Reproductive outcomes associated with delayed clinical cure of metritis in dairy cows.
C. Figueiredo*1, V. Merenda1, E. de Oliveira2, F. Lima2, R. Chebel1, K. Galvao1, J. Santos1, R. Bisinotto1. 1University of Florida Gainesville, FL, 2University of California Davis, CA.

Approximately 20% of cows treated for metritis fail to resolve clinical signs shortly after antimicrobial therapy. Objectives were to evaluate reproductive outcomes, uterine health, and estrous cyclicity associated with delayed clinical cure of metritis. This prospective cohort study included data from 4 experiments performed between 2012 and 2018 in 6 Florida dairies. Metritis was characterized by presence of watery, fetid, reddish-brownish vaginal discharge (VD; VD = 5) within 21 DIM (d 0). Cows with metritis were treated with ampicillin or ceftiofur and paired with counterparts without metritis (NoMet; n = 2,906). On d 11, cows with metritis with VD <5 were classified as cured (MetC; n = 1,136) and those with VD = 5 were classified not cured (MetN; n = 279). Incidence of purulent vaginal discharge (PVD) was evaluated at 32 � 7 DIM using the Metricheck device and estrous cyclicity was evaluated via 2 ultrasonographic exams 10 to 14 d apart, with the last exam between 50 and 67 � 3 DIM. Binary variables were analyzed by logistic regression. Hazard of pregnancy and time to pregnancy were evaluated by Cox's proportional hazard regression models. Services per conception (SPC) was assessed by ANOVA. Incidence of PVD was greater (P < 0.001) for MetN compared with MetC and NoMet (93.2, 79.2, and 43.2%). Proportion of cyclic cows was smaller (P < 0.02) for MetN compared with MetC and NoMet (67.2, 79.9, and 91.8%). Pregnancy per AI (MetN = 28.2, MetC = 29.2, NoMet = 31.8%) and pregnancy loss (MetN = 13.1, MetC = 11.5, NoMet = 13.5%) after first AI did not differ (P > 0.35) among groups. SPC was greater (P = 0.04) for MetN compared with NoMet and intermediate for MetC (3.43, 2.98, 3.15). Hazard of pregnancy was smaller (P < 0.001) for MetN compared with MetC (AHR = 0.72; 95% CI = 0.49 to 0.94) or NoMet (AHR = 0.59; 95% CI = 0.49 to 0.70), and for MetC compared with NoMet (AHR = 0.82; 95% CI = 0.74 to 0.90). Mean days to pregnancy for MetN, MetC, and NoMet were 211, 183, and 170. Delayed clinical cure of metritis was associated with impaired subsequent uterine health, delayed resumption of ovulation postpartum, and decreased hazard of pregnancy.

Keywords: uterine disease, health, pregnancy.

Biography: Caio Cesar Figueiredo was born in Sao Paulo, Brazil. He acquired his DVM degree in 2016 from Universidade Anhembi Morumbi. Caio spent a full semester at the animal reproduction department at University of Florida. In 2017, Caio practiced bovine and equine reproduction in farms throughout Sao Paulo state. He initiated his MS program at University of Florida under the guidance of Dr. Rafael Bisinotto in 2018. His MS degree was awarded in December 2019 and Caio has initiated his PhD program focused on dairy cattle uterine health, applicability of assisted reproduction techniques, and multiple breeding management strategies.