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Association between delayed clinical cure and culling in dairy cows diagnosed with metritis.

C. Figueiredo




Association between delayed clinical cure and culling in dairy cows diagnosed with metritis.
C. Figueiredo*1, V. Merenda1, E. de Oliveira2, F. Lima2, R. Chebel1, K. Galvao1, J. Santos1, R. Bisinotto1. 1University of Florida Gainesville, FL, 2University of California Davis, CA.

Objectives were to assess the risk and timing of culling associated with delayed clinical cure in dairy cows diagnosed with metritis. This prospective cohort study compiled data from 4 experiments performed between 2012 and 2018 in 6 herds located in Florida. Metricheck device was used to evaluate vaginal discharge (VD) within 21 DIM (1 = clear mucus; 2 = mucus with few flecks of pus; 3, = mucus with <50% of pus; 4, = mucus with ≥50% of pus; 5 = watery, fetid, reddish-brownish). Cows with VD = 5 were diagnosed with metritis. Cows diagnosed with metritis (d 0) were treated with either ampicillin or 2 formulations of ceftiofur and paired with cows without metritis counterparts (NoMet; n = 2,906) based on calving date and parity. Cows previously diagnosed with metritis that displayed VD <5 on d 11, were classified as cured (MetC; n = 1,136) and those with VD = 5 were classified as not cured (MetN; n = 279). Risk of culling within 300 DIM was analyzed by logistic regression. Hazard of culling within 60 and 300 DIM were evaluated by Cox's proportional hazard models. Tukey method was used to correct for multiple comparison. Risk of culling was greater (P < 0.02) for MetN compared with NoMet or MetC (22.4, 14.3, and 15.6%). Hazard of culling within 60 DIM was greater (P ≤ 0.001) for MetN compared with MetC (AHR = 2.25; 95% CI = 2.09 to 2.41) or NoMet (AHR = 2.73; 95% CI = 1.75 to 4.25), whereas no difference was observed (P = 0.30) between MetC and NoMet (AHR = 1.21; 95% CI = 0.84 to 1.75). Average intervals to culling were 54 DIM for MetN, 58 DIM for MetC, and 58 DIM for NoMet. Conversely, no difference (P = 0.68) was observed for the hazard of culling within 300 DIM, and the AHR for MetN compared with MetC was 1.15 (95% CI = 0.89 to 1.41), and NoMet was 1.07 (95% CI = 0.75 to 1.51). No difference (P = 0.72) was observed for MetC compared with NoMet (AHR = 0.93; 95% CI = 0.73 to 1.18). Average days to culling were 283 DIM for MetN, 287 DIM for MetC, and 300 DIM for NoMet. Delayed clinical cure of metritis was associated with increased hazard of culling and earlier exit from the herd within the first 2 mo postpartum.

Keywords: uterine disease, health, culling.

Biography: Caio Cesar Figueiredo was born in Sao Paulo, Brazil. He acquired his DVM degree in 2016 from Universidade Anhembi Morumbi. Caio spent a full semester at the animal reproduction department at University of Florida. In 2017, Caio practiced bovine and equine reproduction in farms throughout Sao Paulo state. He initiated his MS program at University of Florida under the guidance of Dr. Rafael Bisinotto in 2018. His MS degree was awarded in December 2019 and Caio has initiated his PhD program focused on dairy cattle uterine health, applicability of assisted reproduction techniques, and multiple breeding management strategies.