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Direct, indirect, and pleiotropic genetic effects associated with calving ease, retained placenta and metritis in US Holstein cows.

R. A. Teixeira

Events

06-23-2020

Abstract:

194
Direct, indirect, and pleiotropic genetic effects associated with calving ease, retained placenta and metritis in US Holstein cows.
R. A. Teixeira*1,2, L. T. Dias1,2, A. Sigdel1, F. Pe�agaricano1. 1University of Florida Gainesville, FL, 2Universidade Federal do Paran� Curitiba, PR, Brazil.

Calving ease, retained placenta and metritis are important traits that directly impact animal welfare, productivity, and farm profitability. These traits are highly correlated, and our goal was to reveal genomic regions with direct and indirect genetic effects. We hypothesized that calving ease affects both retained placenta and the incidence of metritis, while retained placenta has also a direct effect on metritis. Direct, indirect, and pleiotropic genetic effects were detected using both marginal and conditional whole-genome scans. Data consisted of about 28k health records on 13k Holstein cows across the first 6 lactations. Genotype data for 58k SNP markers were available for 6.1k cows with phenotypic records and 1.4k sires in the pedigree. The ssGBLUP method was used to identify genomic regions and individual genes that explain more than 0.5% of the additive genetic variance. Whole-genome scan detected regions on BTA6, BTA11 and BTA17 with direct effects on calving ease. These regions harbor several genes including FAHD2A and NPHP1. Genomic regions on BTA2, BTA10, BTA19, BTA23, BTA25 and BTA29 were found to have direct effects on retained placenta. These regions harbor several genes, including ZNF690 and SNX22, which are involved in caruncle-cotyledon separation. Genomic regions on BTA5, BTA8, BTA12, BTA19 and BTA29 were found to have direct effects on metritis. These regions contain putative candidate genes, such as RBFOX2, MYH9, CCL5, CCL14 and CCL16, which are involved in immunity. Genomic regions having pleiotropic effects were found on BTA14 for calving ease and metritis, and on BTA15 for retained placenta and metritis. Moreover, indirect effects were detected on BTA20 for retained placenta, and on BTA13 for metritis. Overall, our research has multiple benefits, including better understanding of the biology underlying these correlated phenotypes, promote the development of new therapies and mitigation strategies, and contribute to the design of novel breeding strategies using genomic information.

Keywords: dystocia, postpartum uterine disease, structural model.