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Induced endometritis affects production in early lactation.

A. Husnain

Events

06-22-2020

Abstract:

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Induced endometritis affects production in early lactation.
A. Husnain*, U. Arshad, M. B. Poindexter, R. Zimpel, A. Vieira-Neto, Z. Ma, K. C. Jeong, W. W. Thatcher, C. Nelson, J. J. Bromfield, J. E. P. Santos. University of Florida Gainesville, FL.

Objectives were to investigate the impact of induced endometritis on performance in early lactation. The hypothesis was that induced endometritis induces localized and systemic inflammatory responses that depress production. Postpartum Holstein cows without any clinical disease in the first 30 DIM and less than 10% polymorphonuclear cells (PMN) in endometrial cytology had the estrous cycle synchronized starting at 29 DIM. Cows were blocked by parity and genomic breeding value for fertility and, within block, assigned randomly to remain as untreated controls (CON; n = 19) or to receive an intrauterine infusion of 5x108 colony-forming units of Escherichia coli and 5 � 108 colony-forming units of Trueperella pyogenes on d 6 of an estrous cycle at 44 DIM (INF; n = 19). Endometrial cytology was taken on d 2 and 7 after treatment to evaluate PMN and mRNA expression of inflammatory genes. Rectal temperature, milk yield and components were evaluated from d −7 to 7 relative to treatment. Data were analyzed by mixed models with the MIXED and GLIMMIX procedures of SAS. Treatment increased (P < 0.01) the proportion of PMN in the endometrial cytology on d 2 (CON = 3.9 � 1.1 vs. INF = 39.9 � 6.6%) and 7 (CON = 8.5 � 2.2 vs. INF = 19.0 � 4.3%) after infusion. Using a cut-off of 10% PMN as subclinical endometritis (SCE), 28.7 � 9.8 of CON and 91.9 � 5.3 of INF developed SCE (P < 0.001). Rectal temperature did not differ (P = 0.52) between CON and INF and averaged 38.9 and 38.9 � 0.1�C, respectively. Yield of milk in the 7 d following treatment tended (P = 0.09) to be greater in CON than INF (CON = 44.0 vs. INF = 40.9 � 1.8 kg/d). Treatment did not affect the yields of ECM (CON = 42.8 vs. INF = 41.9 � 1.9 kg/d; P = 0.65), fat (CON = 1.45 vs. INF = 1.52 � 0.07 kg/d; P = 0.45), or protein (CON = 1.22 vs. INF = 1.14 � 0.07 kg/d; P = 0.20), but lactose yield was greater (P = 0.02) in CON than INF (CON = 2.37 vs. INF = 2.09 � 0.12 kg/d). The somatic cell score (SCS) did not differ (P = 0.95) between treatments (CON = 2.7 vs. INF = 2.7 � 0.3). Induction of endometritis induced an influx of PMN, increased incidence of SCE and affected yields of milk and lactose in early lactation cows.

Keywords: dairy cow, endometritis, production.