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Dry-off antibiotic use in dairy cattle to cure intramammary infections: A systematic review and network meta-analysis.

C. McMullen



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Dry-off antibiotic use in dairy cattle to cure intramammary infections: A systematic review and network meta-analysis.
C. McMullen*1, J. Sargeant1, D. Kelton1, A. O'Connor2, C. Reedman1, C. Winder1. 1Department of Population Medicine, Ontario Veterinary College, University of Guelph Guelph, ON, Canada, 2Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University East Lansing, MI.

Dry-cow antibiotic therapy is used to both cure existing intramammary infections (IMI) at drying off and to prevent new IMI from occurring during the dry period. IMI increases the risk of clinical mastitis (CM) in the subsequent lactation, therefore, dry-off antibiotics are commonly used during this period to decrease the impact of IMI or CM on milk quality and quantity. The objective of this research was to determine the relative efficacy of dry-off antibiotics labeled for use to cure IMI in dairy cattle through a systematic review and network meta-analysis approach. A systematic search of relevant databases (Medline, CAB Abstracts, Science Citation Index, Conference Proceedings Citation Index — Science, and Agricola), conference proceedings, and FDA summaries was conducted to identify relevant articles. Eligible studies were controlled trials with natural disease exposure evaluating dry-off antibiotic treatment for cure of existing IMI, in comparison to a different antibiotic treatment, a non-antibiotic treatment, or no treatment. From 3749 unique citations identified by the search, there were 149 eligible trials with 236 treatment arms remaining for data extraction, which was completed independently in duplicate. Data from these studies will be synthesized using a network meta-analysis to assess the efficacy of multiple dry-cow antibiotic options through the use of both direct and indirect evidence. If products are equivalent in efficacy, one with a lesser level of importance for human health can be chosen for use by producers. This research will aid veterinarians and dairy producers in making evidence-based decisions concerning antibiotic use and will support the judicious use of antibiotics in dairy cattle.

Keywords: dry cow, mastitis, treatment.

Biography: C.K. McMullen is a second year Master of Science student from the University of Guelph. Her familial ties to a cash-crop operation and background in animal biology have led her to continue her passion for research by using epidemiologic and one health methods to tackle problems within the dairy industry and beyond.