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Benefit of zinc methionine hydroxy analog chelate to increasing tissue enrichment with dietary antagonism in Holstein calves.

H. Tucker

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06-24-2020

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Abstract:

W81
Benefit of zinc methionine hydroxy analog chelate to increasing tissue enrichment with dietary antagonism in Holstein calves.
H. Tucker*, A. Provin. Novus International St Charles, MO.

Bioavailability of Zn sources is an important component of Zn nutrition of dairy cattle. To expand our knowledge of Zn metabolism, further research is needed to elucidate the impact of antagonisms on Zn enrichment in target tissues. The objective of this trial was to determine the effect of a Zn antagonism, elevated S, on bioavailability of Zn from Zn-glycinate (Zn-Gly) and Zn-methionine hydroxy analog chelate (Zn-MHAC) in Holstein calves. Thirty weaned male Holstein calves (BW = 63.5 � 2 kg [mean � SE]) were fed a texturized starter formulated to meet nutrient requirements but varied in sodium sulfate level for 32 d. On d 30, calves were orally administered 0 (n = 6) or 8 (n = 24) mg of Zn from each of 2 sources: 67Zn-Gly and 70Zn-MHAC at 0h. Blood was collected via catheters before isotope administration and 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 8, 10, 12, 24, 36, and 48 h after isotope administration for determination of isotope enrichment. Calves were euthanized 48 h after isotope administration with target tissues weighed and sampled for determination of isotope enrichment via ICP-MS. Data were analyzed with the MIXED procedure of SAS 9.4, with significance declared at P < 0.05 and trends at 0.05 ≤ P < 0.10. Though dry matter intake differed (P = 0.07), calves receiving the High diet (11.3 � 0.2 g S/d) consumed 2.9 times more S than Low diet (3.9 � 0.2 g S/d). Tissue isotope enrichment decreased (P < 0.01) with High S diet for rumen, reticulum, omasum, duodenum, jejunum, ileum, kidney, lung, and spleen (P = 0.07). Tissue isotope enrichment increased (P = 0.08) with High S diet in thymus. Tissue isotope enrichment was greater (P ≤ 0.05) with Zn-MHAC compared with Zn-Gly for rumen, reticulum, omasum, abomasum, duodenum, jejunum, ileum, kidney, lung, heart, spleen, and thymus. No significant interaction of S level and Zn source was observed. The impact of high dietary S on tissue Zn isotope enrichment demonstrates efficacy of this antagonistic model in ruminants. Moreover, changes in Zn enrichment of the splanchnic tissues demonstrates their high metabolic requirement for Zn. Finally, the improved enrichment from Zn-MHAC demonstrates greater bioavailability independent of antagonism presence.

Keywords: bioavailability, stable isotope, zinc.