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Effect of timing of prepartum vaccination relative to pen change of dairy cows on lying time and serum glucose, nonesterified fatty acids, and calcium at calving.

B. T. Menichetti

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06-22-2020

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Abstract:

M35
Effect of timing of prepartum vaccination relative to pen change of dairy cows on lying time and serum glucose, nonesterified fatty acids, and calcium at calving.
B. T. Menichetti*1, A. Garcia-Guerra2, J. Lakritz3, W. P. Weiss5, J. S. Velez4, D. Merchan4, G. M. Schuenemann1. 1Department of Veterinary Preventive Medicine, The Ohio State University Columbus, OH, 2Department of Animal Sciences, The Ohio State University Columbus, OH, 3Department of Veterinary Clinical Sciences, The Ohio State University Columbus, OH, 4Aurora Organic Farms Boulder, CO, 5Department of Animal Sciences, The Ohio State University Wooster, OH.

The objective was to assess the effects of timing of prepartum vaccination (Enviracor J5 and Scourguard4; Zoetis) relative to pen movements of gestating dairy cows on lying time (LT), energy status (plasma glucose and nonesterified fatty acids [NEFA]) and plasma calcium at calving. Briefly, pregnant multiparous Holstein cows (n = 296) from one dairy herd were randomly allocated into 1 of 3 treatment groups at 35 � 3 d before anticipated parturition (dpp): 1) vaccination at 28 d and cow pen change at 21 d (V28-M21; n = 104), 2) vaccination and cow pen change at 28 � 3 d (V28-M28; n = 96) and 3) vaccination and cow pen change at 21 � 3 d (V21-M21; n = 96). All prepartum cows were loosed-housed in barns with free access to a contiguous dry-lot patio. Every other week, a group of 43 to 53 animals were enrolled and electronic data loggers (IceQube, IceRobotics, Edinburgh, UK) were fitted to the hind leg of individual cows to assess their LT. Blood samples were collected at 28, 26, 21, 19, 14 dpp and at calving. Data were analyzed using MIXED procedure of SAS accounting for BCS, parity and cohort of enrollment. Regardless of treatment group, LT of prepartum cows ranged from 12 to 13.2 h/d. Cow movement with vaccination reduced LT (P = 0.0003) by 36 min/d for the first 3 d thereafter compared with cow movement alone. V21-M21 cows had higher concentrations of NEFA at 19 (170 �Eq/L; P < 0.0001) and 14 dpp (161 �Eq/L; P = 0.01) compared with V28-M28 (109 �Eq/L and 130 �Eq/L, respectively) or V28-M21 cows (102 �Eq/L and 141 �Eq/L, respectively) while no differences among groups were observed at calving. At calving, V28-M21 cows had higher (P = 0.04) glucose concentration (114.5 mg/dL) compared with V21-M21 cows (101.6 mg/dL) with V28-M28 cows intermediate to other 2 groups (107.2 mg/dL). V28-M21 cows had reduced proportion of hypocalcemia (≤8.0 mg/dL; 18.7%; P = 0.004) compared with V21-M21 (37.3%) but did not differ from V28-M28 cows (24.8%). These findings suggest that vaccinating cows at 28 dpp and pen change at 21 dpp would benefit common prepartum changes in metabolism.

Keywords: prepartum, fatty acids, hypocalcemia.