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The effect of vaccination with a Mannheimia haemolytica subunit vaccine on milk yield in lactating dairy cows.

M. Overton

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06-22-2020

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Abstract:

M38
The effect of vaccination with a Mannheimia haemolytica subunit vaccine on milk yield in lactating dairy cows.
M. Overton*, M. Armfelt. Elanco Animal Health Greenfield, IN.

Many herds in the US use a Mannheimia vaccine in lactating dairy cows as an aid in reducing the impact of Bovine Respiratory Disease (BRD. A prospective, randomized clinical trial was conducted to evaluate milk production changes associated with the administration of a Mannheimia haemolytica subunit vaccine (MHSV; Nuplura PH, Elanco Animal Health, Greenfield, IN). A total of 972 lactating Holstein dairy cow were randomized into 1 of 3 study groups on a Midwestern dairy. Daily milk production during the 7 d before treatment was averaged and used as the baseline for comparison. Lactation Group (1, 2, or 3+), DIM, and 7-d pretreatment average milk production (41.7 kg) was not different across the groups. Cows were treated at the end of the morning milking on vaccination day according to group assignment of (MHSV), Saline, or Negative Control (no injection). Cow-level milk production was then averaged for vaccination day (Day 0) and the following 2 d. The 3-d post-treatment milk average was then compared with the baseline 7 d average milk yield for each group. The association between vaccination with MHSV and subsequent milk production changes while controlling for explanatory factors was compared with both the Saline and Negative Control groups using ANOVA and fitting least squares using JMP Pro 14.3.0. Negative Control cows served as the referent value. Saline group's decline in milk was 0.25 kg greater than Negative Control cows but the difference was not significant (P = 0.57). The Nuplura group's decline in milk was 0.7 kg more than the Negative Control, P = 0.02, but the Saline Nuplura declines were not significantly different (P = 0.17). On Day 1, the Nuplura group loss was 1.18 kg more than the Negative Control cows (P < 0.01) but the Saline group's loss of 0.13 kg was not different from Negative Control (P = 0.92). On Day 0 and Day 2, there were no significant differences between groups.

Keywords: Mannheimia vaccine, dairy cattle, bovine respiratory disease.