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Assessment of the effects of intrauterine dextrose on clinical cure rate, body condition score, and concentration of β-hydroxybutyrate and haptoglobin in postpartum dairy cows diagnosed with clinical metritis.

A. A. Barragan

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06-22-2020

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Abstract:

M37
Assessment of the effects of intrauterine dextrose on clinical cure rate, body condition score, and concentration of β-hydroxybutyrate and haptoglobin in postpartum dairy cows diagnosed with clinical metritis.
A. A. Barragan*1, J. Hamilton1, E. Hovingh1, M. Martinez1, L. Byler1, S. Bas2, J. Zug3, S. Haan3. 1Department of Veterinary and Biomedical Sciences, Penn State University University Park, PA, 2Phytobiotics Futterzusatzstoffe GmbH Bvd Villa Maria, C�rdoba, Argentina, 3Zugstead Farm Mifflintown, PA.

The objective of this study was to assess the effects of intrauterine dextrose (50%) infusion on clinical cure rate, body condition score (BCS), β-hydroxybutyrate (BHB) and systemic inflammation (haptoglobin; HP) in dairy cows diagnosed with clinical metritis (CM). Cows (n = 351) from a dairy farm located in Pennsylvania were screened at 7 � 3 DIM using a Metricheck device to assess vaginal discharge. Cows that presented a fetid red-brownish watery vaginal discharge (n = 53) were classified as CM cows, blocked by parity and randomly assigned to 1 of 2 groups: 1) CONV (n = 27): 2 injectable (SC) administrations of ceftiofur (6.6 mg/Kg; Excede, Zoetis Inc.) 72 h apart; and 2) DEX (n = 26): 3 intrauterine infusions of dextrose (50%; 1 L/cow) 24 h apart. Furthermore, cows that presented a normal vaginal discharge at 7 � 3 DIM (i.e., dense clear discharge; healthy group; HLT; n = 27) were randomly selected and matched by parity to CONV and DEX cows. Cows were re-screened at 14 � 3 DIM and 21 � 3 DIM to assess clinical cure rate. Body condition score was assessed and blood samples (i.e., BHB, HP) were collected at enrollment and at 14 � 3 DIM and 21 � 3 DIM. The data were analyzed using the MIXED and GLIMMIX procedures of SAS as a randomized complete block design. There was no difference in clinical cure rate at 14 � 3 DIM (CONV = 50.27 � 12.49%; DEX = 45.9 � 12.37%) and 21 � 3 DIM (CONV = 88.05 � 6.59%; DEX = 88.51 � 6.35%) between CONV and DEX groups. HLT cows tended to have a higher BCS at 21 � 3 DIM compared with cows in the CONV and DEX groups (CONV = 3.05 � 0.09 pts.; DEX = 2.96 � 0.09 pts.; HLT = 3.25 � 0.10 pts.). There was no difference in BHB concentrations between study groups. Overall, cows treated with DEX had higher HP concentrations compared with HLT cows (CONV = 119.91 � 23.52 �g/mL; DEX = 153.06 � 22.75 �g/mL; HLT = 71.52 � 23.91 �g/mL). These results suggest that, although intrauterine infusion of dextrose may achieve similar clinical cure rates as a conventional antibiotic treatment, the treatment may not be as effective on decreasing systemic inflammation in CM cows.

Keywords: metritis, dextrose, inflammation.