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Assessment of the effects of intrauterine dextrose infusion on clinical cure rate, number of health events, culling rate, and reproductive performance in postpartum dairy cows diagnosed with clinical metritis.

A. A. Barragan

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06-23-2020

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Abstract:

T92
Assessment of the effects of intrauterine dextrose infusion on clinical cure rate, number of health events, culling rate, and reproductive performance in postpartum dairy cows diagnosed with clinical metritis.
A. A. Barragan*1, J. Hamilton1, E. Hovingh1, L. Byler1, M. Martinez1, S. Bas2, J. Zug3, S. Haan3. 1Department of Veterinary and Biomedical Sciences, Penn State University University Park, PA, 2Phytobiotics Futterzusatzstoffe GmbH Bvd Villa Maria, C�rdoba, Argentina, 3Zugstead Farm Mifflintown, PA.

The objective of this study was to assess the effects of intrauterine dextrose (50%) infusion on clinical cure rate, number of health events, culling rate and reproductive performance in dairy cows diagnosed with clinical metritis (CM). Cows (n = 351) from a dairy farm located in Pennsylvania were screened at 7 � 3 DIM using a Metricheck device to assess vaginal discharge. Cows that presented a fetid red-brownish watery vaginal discharge (n = 53) were classified as CM cows, blocked by parity and randomly assigned to 1 of 2 groups: 1) CONV (n = 27): 2 injectable (SC) administrations of ceftiofur (6.6 mg/kg; Excede, Zoetis Inc.) 72 h apart; and 2) DEX (n = 26): 3 intrauterine infusions of dextrose (50%; 1 L/cow) 24 h apart. Furthermore, cows that presented a normal vaginal discharge at 7 � 3 DIM (i.e., dense clear discharge; healthy group; HLT; n = 27) were randomly selected and matched by parity to CONV and DEX cows. Cows were re-screened at 14 � 3 DIM and 21 � 3 DIM to assess clinical cure rate. The number of other health events, after CM was diagnosed, and culling rate during the first 60 DIM, and reproductive performance parameters (i.e., DIM to conception, number of services required to conceive) for the first 150 DIM were collected from on-farm computer records. The data were analyzed using the MIXED, GLIMMIX and PHREG procedures of SAS as a randomized complete block design. There was no difference in clinical cure rate at 14 � 3 DIM (P -value = 0.77; CONV = 50.27 � 12.49%; DEX = 45.9 � 12.37%) and 21 � 3 DIM (P -value = 0.96; CONV = 88.05 � 6.59%; DEX = 88.51 � 6.35%) between CONV and DEX groups. There was no difference in the number of health events and culling rate in the first 60 DIM between study groups. Cows treated with DEX required more days to become pregnant compared with HLT cows (P -value = 0.03; CONV = 95.4 � 4.92 d; DEX = 102.73 � 5.68 d; HLT = 81.4 � 5.68 d). These results suggest that intrauterine infusion of dextrose may have similar outcomes in regard to clinical cure of CM as a conventional antibiotic treatment; however, the latter treatment may decrease the number of days to conception in CM cows.

Keywords: metritis, dextrose, fertility.