Adsa Logo White Adsa Title White

Immunoglobulin G and serum total protein concentration assessment in dairy calves over the first 2 weeks of age.

A. Correa



Join A. Correa on this page for a live text chat!
6:00 PM - 8:00 PM GMT


Immunoglobulin G and serum total protein concentration assessment in dairy calves over the first 2 weeks of age.
A. Correa*, A. Villadecabres, N. Silva-del-R�o. Veterinary Medicine Teaching and Research Centre, University of California-Davis Tulare, CA.

The aims of the present study were to: (1) evaluate changes of serum IgG (SIgG) and serum total protein (STP) concentration of dairy calves during the first 16 d of life, and (2) investigate if predictive models for SIgG concentration based on STP could be improved when adjusted by hematocrit (Hct). Enrolled calves (24 Jersey, 41 Holstein) arrived at a commercial raising operation from 2 source dairies. Prior arrival, calves were bottle fed 3 meals of pasteurized colostrum (2 L per meal) at (mean � SD) 38 � 26 min, 7 h 19 min � 1 h 5 min, and 7 h 45 min � 1h after birth. Concentration of SIgG (single radial immunodiffusion), STP (BRIX refractometer), and blood Hct (centrifugation), were determined in blood samples collected from calves immediately after arrival at the calf operation (1 d) and 4, 8, 12 and 16 d of life. The MIXED procedures of SAS were used to evaluate changes over time of SIgG and STP as well as the predictive value of STP corrected by Hct. At 1 d, SIgG ranged from 252 and 10,619 mg/dL (mean: 2,124 mg/dL), STP from 3.6 to 9.3 g/dL (mean: 6.0 g/dL) and Hct from 18 to 44% (mean: 30%). During the study period, on 1, 4, 8, 12 and 16 d, calves had SIgG <1,500 mg/dL (n = 11, 20, 28, 36 and 45 respectively) and serum TP <5.5 g/dL (n = 15, 26, 31, 47 and 63 respectively). Relative to 1 d, SIgG tended to decrease at 4 d (205 mg/dL), and it was significantly lower at 8 d (343 mg/dL), 12 d (583 mg/dL) and 16 d (747 mg/dL). Relative to 1 d, STP concentration significantly decrease with time at 4 d (0,344 g/dl), 8 d (0.470 g/dl), 12 d (0.704 g/dl) and 16 d (1.107 g/dl). There was a moderate correlation between SIgG at 1 d with STP at 1 d (r = 0.66), 4 d (r = 0.61, 8 d (r = 0.63), 12 d (r = 0.54), and 16 d (r = 0.66). The model fit for SIgG prediction did not improve when STP was adjusted by Hct. In summary, our results indicate that SIgG and STP declined during the first 2 weeks of life. Further studies should determine the specificity and sensitivity of SIgG and STP during the first 2 weeks of life as diagnostic tools for failure of passive transfer of colostrum.

Keywords: calf, immunoglobulin, total protein.