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Effects of a cashew nut shell extract on energetic metabolism and inflammatory biomarkers in transition dairy cows.

B. M. Goetz



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Effects of a cashew nut shell extract on energetic metabolism and inflammatory biomarkers in transition dairy cows.
B. M. Goetz*1, E. A. Horst1, E. J. Mayorga1, M. A. Abeyta1, S. Rodriguez-Jimenez1, S. Carta1, C. Hikita2, T. Watanabe2, L. H. Baumgard1. 1Iowa State University Ames, IA, 2Idemitsu Kosan Co., Ltd Tokyo, Japan.

Objectives were to evaluate the effects of cashew nut shell extract (CNSE, anacardic acid 59% and cardol 18%) on energetic metabolism and inflammatory biomarkers in periparturient Holstein cows. The formulated CNSE final granule contained 50% CNSE. Fifty-one multiparous cows were stratified by previous 305 ME and parity and assigned to 1 of 2 treatments 21 d before expected calving and continued until 28 DIM: (1) CON (control diet; n = 17) or (2) CNSE-5.0 (control diet and 5.0 g/d CNSE granule; n = 34). Following parturition, 17 cows from the CNSE-5.0 treatment were reallocated into a third treatment group: CNSE-2.5 (control diet and 2.5 g/d CNSE granule; n = 17) resulting in 3 total treatments postpartum: 1) CON, 2) CNSE-2.5 and 3) CNSE-5.0. Treatments were mixed with ground corn and top-dressed on the base TMR. Blood samples were obtained on d −14, −7, 3, 7, 14, 21, and 28 relative to expected calving. Effects of treatment, time, and treatment � time were assessed using PROC MIXED. Circulating glucose and insulin prepartum were similar between treatments. Following parturition, glucose (5.5%; P = 0.02) and insulin (19%, P = 0.07) concentrations from CNSE-fed cows decreased relative to CON. NEFA did not differ between treatments prepartum, however there was a quadratic response to increasing CNSE levels on circulating NEFA postpartum, as they were elevated in CNSE-2.5 relative to CON and CNSE-5.0 cows (31 and 23%, respectively; P = 0.01). No effects of dietary CNSE were observed for BHB concentrations prepartum. After calving, circulating BHB tended to increase in CNSE cows (14%, P = 0.05). Prepartum and postpartum BUN concentrations were unaltered by CNSE supplementation. Circulating serum amyloid A and lipopolysaccharide-binding protein peaked immediately after calving and progressively decreased with time but was unaffected by treatment. Cortisol was unaltered by treatment. In summary, CNSE supplementation mildly altered energetics (but without clinical relevance) in the periparturient period and had little to no effect on inflammatory metrics.

Keywords: periparturient, anacardic acid, methane.

Biography: Brady is a Master's student under the direction of Dr. Lance Baumgard.