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Feeding rumen-protected lysine prepartum enhanced plasma indicators of liver function and increased oxidative burst capacity postpartum in Holstein cows.

L. K. Fehlberg

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06-24-2020

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Abstract:

W53
Feeding rumen-protected lysine prepartum enhanced plasma indicators of liver function and increased oxidative burst capacity postpartum in Holstein cows.
L. K. Fehlberg*1, A. R. Guadagnin1, B. L. Thomas1, Y. Sugimoto2, I. Shinzato2, F. C. Cardoso1. 1University of Illinois Urbana, IL, 2Ajinomoto Co. Inc Tokyo, Japan.

A negative energy and protein balance during the periparturient period increases stress in dairy cows and may lead to compromised liver and immune function. This experiment was conducted to determine the effects of feeding rumen-protected Lys (RPL; AjiPro-L Generation 3, Ajinomoto Heartland Inc., Chicago, IL) prepartum (0.54%DM of TMR), postpartum (0.395%DM of TMR), or both on blood metabolites related to immune and liver function. Seventy-five multiparous Holstein cows, blocked by parity, previous 305-d mature-equivalent milk production, expected calving date, and body condition score during the far-off dry period were assigned to 1 of 4 dietary treatments in a randomized, complete block design with a crossover of a diet with RPL (L) or without (C). Treatments consisted of TMR topdressed with RPL prepartum and postpartum (LL), with RPL prepartum and without RPL postpartum (LC), without RPL prepartum and with RPL postpartum (CL), and without RPL prepartum and postpartum (CC). Blood samples were taken −7 � 0.5, 0 � 0.5, 7 � 0.9, and 14 � 0.9 d relative to calving (DRC) for detection of phagocytosis and oxidative burst of neutrophils and monocytes in whole blood. Blood samples were also collected for plasma metabolites on −7 � 0.5, −1 � 0.6, 0 � 0.5, 7 � 0.9, 14 � 0.9, and 28 � 0.3 DRC. Statistical analyses was performed using MIXED procedure of SAS. Phagocytosis of monocytes in whole blood postpartum tended to be greater (P = 0.06) for cows in C (21.87%) compared with those in L (19.97%). Oxidative burst of monocytes postpartum in whole blood was greater (P = 0.04) at 7 DRC for cows in LL and LC (65.64%) compared with those in CC and CL (57.51%) but not at 14 DRC (P = 0.67). Plasma concentrations of aspartate aminotransferase, indicative of liver function, were lower (P < 0.01) at 14 DRC for cows in LL and LC (73.62 U/L) compared with those in CC and CL (86.81 U/L) but not at 7 or 28 DRC (P = 0.39). In summary, consumption of intestinally available Lys prepartum enhances liver function postpartum and increased the oxidative burst capacity of monocytes.

Keywords: lysine, oxidative burst, liver function.