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Clinical evaluation of diarrhea calves submitted to therapeutic protocols containing sulfonamides with different routes of administration.

E. Schmitt

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06-22-2020

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Abstract:

M113
Clinical evaluation of diarrhea calves submitted to therapeutic protocols containing sulfonamides with different routes of administration.
R. Klaus1, L. V. Vieira1, A. D. C. de Matos1, U. S. Londero1, J. Halfen1, V. R. Rabassa1, E. Schmitt*1, R. A. Pereira2, M. N. Corr�a1, A. A. Barbosa1, F. A. B. Del Pino1, J. Feij�1, C. C. Brauner1. 1Federal University of Pelotas Pelotas, Rio Grande do Sul, Brazil, 2Laboratory Ibasa Porto Alegre, Rio Grande do Sul, Brazil.

Neonatal diarrhea is 1 of the most important diseases in the dairy calve production system, mostly by affecting negatively the growth and performance of young calve, which may be associated with low treatment effectiveness. This study was designed to evaluate the clinical, hematological and growth performance of calves diagnosed with diarrhea against 3 treatments using sulfonamides. Fourteen Holstein calves were divided into 3 groups according to the administration route: oral (ORAL, n = 5); injectable (INJ, n = 4), and oral plus injectable (ORAL + INJ, n = 5). Clinical evaluations and fecal scores were performed on d 0, 3, 5 and 7 in relation to the day of diarrhea diagnosis. Fecal samples were collected on d 0 and 7, to identify the bacterial agent, performed by PCR, antibiogram and coproparasitological exams. Measurements of chest perimeter, withers height, and croup width were performed weekly until 30 d of age, while weight up to 60 d. The INJ group presented better (P < 0,05) growth performance and a trend (P = 0,06) to lower fibrinogen when compared with the others. Escherichia coli was identified in 100% (n = 17) of collected samples and the virulence genes, identified by PCR: hlyA, stx1, estIa, and eae, that are characteristic of enterohemorrhagic E. coli (EHEC) a producer of shiga toxin, enterotoxigenic (ETEC) and enteropathogenic (EPEC), respectively. Of all samples collected, 82.35% (n = 14/17) were sensitive to the sulfonamides and 17.65% (n = 3/17) resistant through in vitro sensitivity test. An association was observed between sensitive samples and the stx1 gene. In this sense, the results suggest a greater prevalence of genes related to hemolysin. All treatments seem to be efficient by controlling body temperature and decrease the fecal scores of the treated calves. However, the INJ treatment seems to have a less inflammatory response and improvements on growth performance, being the better treatment for diarrhea caused by E. coli.

Keywords: antimicrobial, Escherichia coli, growth performance.