Adsa Logo White Adsa Title White

The effect of a sanguinarine supplementation on feed intake, weight gain, hematology, and serum chemistry of calves.

H. K. J. P. Wickramasinghe

Events

06-24-2020

Join H. K. J. P. Wickramasinghe on this page for a live text chat!
6:00 PM - 8:00 PM GMT

Abstract:

W68
The effect of a sanguinarine supplementation on feed intake, weight gain, hematology, and serum chemistry of calves.
H. K. J. P. Wickramasinghe*1, N. Stepanchenko1, C. A. Kaya2, J. V. V. Silva1, S. Bas3, F. R. B. Ribeiro3, J. A. D. R. N. Appuhamy1. 1Department of Animal Science, Iowa State University Ames, IA, 2Dicle University Diyarbakir, Turkey, 3Phytobiotics North America LLC Cary, NC.

Plant-derived alkaloids such as sanguinarine are found to be beneficial in improving growth performance, and the immunity of animals. The objective of the present study was to examine the effects of a Macleaya cordata extract (MCE), standardized to contain 1.5% of sanguinarine on DMI, weight gain, weight gain: DMI (FCE), hematology, and serum chemistry of young calves. Forty (20 male and 20 female) crossbred dairy-beef calves of 6.0 � 2.0 d of age were used. Calves were matched for age, sex, and BW and assigned to 4 MCE doses; 0 (CTL), 2.0 and 4.0 (D1), 5.0 and 10 (D2), and 10 and 20 (D3) g/calf/d in pre- and post-weaning, respectively. A milk replacer (MLR, 12% solid in 6.0 L/d) was bottle-fed until calves were 49 d of age. MCE was fed for 90 d mixing daily in MLR pre-weaning and top-dressing on a starter feed post-weaning. Body weight, hematology and serum chemistry were measured on 0, 45 (around weaning), and 90 d. The hematology and serum chemistry analyses were performed in a GLP-certified laboratory (Quality Veterinary Laboratory, Davis CA). The treatment effects were analyzed with a model including fixed effects of treatment (the MCE dose), sex, age, and random effect of calf. The baseline measurements of hematology and serum chemistry were included as covariates in the model. The association of MCE with each response variable was tested using linear and quadratic orthogonal contrasts. The DMI (MLR + starter feed) of pre-weaned calves linearly (P < 0.001) increased with MCE dose. The MCE dose had a quadratic relationship with starter intake post-weaning (P = 0.021). Weight gain and FCE did not change with MCE dose pre- or post-weaning. No hematology parameter changed with MCE dose (P > 0.050). All serum chemistry parameters except creatinine were similar (P > 0.050) among MCE doses. Creatinine linearly increased (P = 0.049) with MCE dose. Overall, MCE supplementation at 10 (pre-weaning) or 20 (post-weaning) g/d appeared to be safe in calves. Performance improvements for MCE could be captured with a larger sample size.

Keywords: sanguinarine, feed intake, calves.